If you are sourcing 4-Tolylboronic acid CAS 5720-05-8, you are typically looking for a reliable aryl-boron building block for palladium-catalyzed cross-coupling, especially Suzuki–Miyaura reactions. I identify this material as 4-methylphenylboronic acid, also known as p-tolylboronic acid. Its commonly reported molecular formula is C7H9BO2, with a molecular weight of approximately 135.96 g/mol.
This guide explains how I evaluate its identity, specifications, application fit, purchasing risks, and supplier capability. I also show which questions buyers should ask before requesting a quotation, sample, or larger production quantity from a chemical manufacturer or exporter such as Maison Chemical.
This guide is intended for pharmaceutical, agrochemical, fine chemical, materials science, and academic research buyers who need a defined supply of 4-Tolylboronic acid. It is also useful for procurement teams comparing laboratory quantities with larger project requirements. Because the correct grade depends on the reaction and downstream use, I recommend treating the product specification, analytical documentation, packaging, and delivery plan as one sourcing decision.
The material may be purchased for route scouting, process development, medicinal chemistry, custom synthesis, or manufacturing support. The appropriate supplier is not selected only by unit price. Identity confirmation, lot consistency, impurity control, documentation, and communication during repeat ordering can have a direct effect on project continuity.
4-Tolylboronic acid contains a boronic acid group attached to a para-methyl-substituted aromatic ring. In practical synthesis, the boronic acid functionality is valuable because it can participate in carbon–carbon bond-forming reactions under suitable catalytic and basic conditions. The para-methyl group remains part of the final aryl fragment and can influence the electronic and steric profile of the product being prepared.
Its principal synthetic role is as an aryl donor in Suzuki–Miyaura coupling with suitable aryl or vinyl halides and related electrophilic partners. Actual performance depends on the catalyst system, base, solvent, temperature, reaction time, substrate structure, and handling of the boronic acid. I therefore recommend using supplier data as a starting point rather than assuming that one reaction protocol will apply to every substrate.
Medicinal chemistry teams may use 4-Tolylboronic acid to introduce a 4-methylphenyl group into a candidate molecule. This can support the preparation of analog libraries during structure–activity relationship studies. The material is often most useful when a project requires rapid access to multiple biaryl or substituted alkene structures from modular intermediates.
In agrochemical and specialty chemical development, the compound can serve as an intermediate for building more complex aromatic structures. Its suitability depends on the target route and the tolerance of the process to residual metals, inorganic salts, water, and other trace impurities. For scale-up, I would request a specification that reflects the actual process risk rather than relying only on a nominal purity value.
Research laboratories may use small quantities for reaction screening, reference experiments, and method development. Process development groups generally need more information, including lot-to-lot analytical comparison, packaging details, retest or expiry information where applicable, and a practical replenishment plan. These requirements become more important when the compound is used repeatedly across several development stages.
Buyers may encounter 4-Tolylboronic acid offered in different package sizes and specification levels rather than fundamentally different chemical types. Common purchasing categories include research-scale material, synthesis-grade material, and project-specific or production-support material. The exact available grade should be confirmed with the supplier because commercial specifications can vary by manufacturer, intended use, and analytical method.
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| Specification area | What I recommend checking | Why it matters |
|---|---|---|
| Identity | CAS number, chemical name, formula, molecular weight, and analytical identification | Confirms that the quoted material matches the required structure |
| Assay or purity | Reported value, test method, and acceptance limit | Helps compare suppliers on a consistent basis |
| Impurity profile | Related substances, residual solvents, inorganic residues, and metals when relevant | Supports reaction robustness and downstream quality control |
| Physical form | Appearance, color description, and packaging condition | Provides a practical check during receiving and inspection |
| Documentation | Certificate of analysis, safety data sheet, and batch information | Supports internal approval, safety review, and traceability |
A quoted purity such as 98% or 99% should never be interpreted without the associated test method and specification basis. These percentages are common commercial reference points, not a guarantee of a particular supplier’s lot. At Maison Chemical, I recommend confirming the requested assay, analytical method, documentation package, and any additional impurity limits before final quotation.
First, I would document whether the material is needed for discovery chemistry, process development, or commercial manufacturing support. I would also record the expected consumption, reaction sensitivity, and any restrictions on residual metals or solvents. This information allows the supplier to recommend a suitable specification instead of offering a generic product without context.
Ask the supplier to confirm the name 4-Tolylboronic acid, CAS 5720-05-8, molecular formula C7H9BO2, and approximate molecular weight 135.96 g/mol. The purchase order, label, certificate of analysis, and safety data sheet should use consistent identification. If the project involves regulated or tightly controlled documentation, clarify whether additional traceability information is required before shipment.
Compare assay, appearance, water or moisture information when relevant, residual solvents, metals, and related substances. I would also ask whether the reported result represents a typical value or a release specification. A supplier that can explain the analytical method and provide batch-specific documentation offers a stronger basis for technical approval than a quotation containing only a price and product name.
Request pricing for the actual quantity tiers required by your project, such as laboratory, pilot, and repeat-order volumes. Lead time can vary according to stock status, production scheduling, packaging, export documentation, and destination requirements. A practical inquiry should therefore specify the target quantity, delivery location, required documents, and desired arrival window rather than asking only for a price per kilogram.
There is no universally valid price, minimum order quantity, or delivery time for 4-Tolylboronic acid because these variables depend on grade, quantity, packaging, manufacturing status, and destination. Small research quantities often carry a different cost structure from larger orders because packaging, testing, and handling represent a larger proportion of the transaction. Larger quantities may improve unit economics, but they should be balanced against storage conditions, consumption rate, and material shelf-life or retest requirements.
For international sourcing, I recommend requesting a written quotation that states product specification, pack size, available quantity, production or stock status, Incoterms where applicable, payment terms, and document availability. Buyers should also clarify whether the quoted lead time begins after purchase order confirmation, payment, technical approval, or another milestone. This prevents avoidable misunderstandings during project planning.
As a manufacturer, supplier, and exporter of organic boronic acids, Maison Chemical can support buyers by clarifying product identity, specification expectations, packaging options, and inquiry requirements. I recommend sharing your intended quantity, application stage, target purity, destination, and documentation needs at the beginning of the discussion. This helps us determine whether a standard commercial specification or a project-specific review is more appropriate.
4-Tolylboronic acid CAS 5720-05-8 is a practical aromatic building block for synthesis programs that require a para-methylphenyl fragment, particularly in suitable Suzuki–Miyaura coupling routes. The best purchasing decision depends not only on nominal purity, but also on verified identity, lot-specific analytical evidence, impurity expectations, packaging, and reliable supply planning.
To begin a qualified sourcing discussion with Maison Chemical, prepare the required quantity, application stage, target specification, delivery destination, and documentation requirements. I can then help assess the appropriate supply option, clarify available packaging and lead time, and determine whether a sample or batch-specific technical review is needed before order placement.
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