4-Trifluoromethylphenylboronic acid, CAS 128796-39-4, is an aryl boronic acid used primarily as a coupling partner in palladium-catalyzed Suzuki–Miyaura reactions. I identify this material by its systematic structure, 4-(trifluoromethyl)phenylboronic acid, molecular formula C7H6BF3O2, and calculated molecular weight of approximately 189.93 g/mol. It can help introduce a 4-trifluoromethylphenyl group into pharmaceutical, agrochemical, and advanced organic intermediates. At Maison Chemical, I support buyers by aligning identity, purity requirements, packaging, documentation, and delivery expectations before a purchase is confirmed.
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This guide is intended for pharmaceutical process chemists, medicinal chemistry teams, agrochemical researchers, custom synthesis companies, procurement professionals, and distributors sourcing 4-Trifluoromethylphenylboronic acid. It is also useful for buyers comparing suppliers for research quantities, process-development batches, or commercial manufacturing programs. Because the required specification can vary significantly by application, I recommend treating the product specification as a project-specific document rather than assuming that one grade fits every use.
The material may be purchased for laboratory screening, route development, scale-up, or recurring production. Each situation requires a different balance of purity, analytical documentation, packaging, availability, and price. A reliable sourcing decision therefore begins with the intended reaction and ends with confirmation of the supplier’s quality and logistics capabilities.
4-Trifluoromethylphenylboronic acid contains both an aryl group substituted with trifluoromethyl and a boronic acid functional group. The boronic acid group is valuable because it can participate in carbon–carbon bond formation, especially when paired with an aryl or vinyl halide under Suzuki–Miyaura coupling conditions. The trifluoromethyl substituent can also influence the electronic and lipophilic properties of the final molecule, which is one reason this building block is considered in medicinal and crop-protection chemistry.
The CAS number is 128796-39-4, and the molecular formula is C7H6BF3O2. Based on the formula, the molecular weight is approximately 189.93 g/mol, so 1 mmol corresponds to about 189.93 mg before accounting for purity, assay basis, or actual water content. These values are useful for stoichiometric planning, but I still advise buyers to verify the supplier’s current specification sheet and certificate of analysis before using the material in a controlled process.
The most common procurement format is the isolated solid supplied in a sealed container. This format gives the user flexibility to prepare a solution or charge the material directly into a reaction. The appropriate package size depends on consumption, handling procedures, stability information, and the buyer’s internal controls.
Research users may focus on identity, assay, and basic analytical data, while process-development teams often require tighter control of related substances, residual solvents, inorganic residues, water content, and lot-to-lot consistency. I do not assume that a product described as “high purity” meets a customer’s process specification. Instead, I recommend defining the acceptance criteria in writing and reviewing a representative COA before order placement.
Some buyers require a specific label format, batch traceability, SDS, COA, packing configuration, or export document set. Other buyers may need packaging designed for repeated manufacturing use or for distribution through a regulated supply chain. These requirements should be discussed before quotation because they can affect cost, preparation time, and shipping arrangements.
The primary use of 4-Trifluoromethylphenylboronic acid is as an aryl donor in cross-coupling chemistry. In a typical Suzuki–Miyaura route, the boronic acid reacts with an appropriate aryl, heteroaryl, or vinyl halide in the presence of a catalyst, base, and suitable reaction medium. The exact catalyst system, temperature, base, solvent, concentration, and work-up depend on the coupling partners and the target molecule.
Medicinal chemistry teams may use this compound to create analogues containing a trifluoromethyl-substituted phenyl group. The same type of transformation may be relevant to pharmaceutical intermediates, reference compounds, screening libraries, and route scouting. In agrochemical research, the building block may be evaluated when a fluorinated aromatic motif is needed in an intermediate or active-ingredient development program.
Not every coupling route is equally compatible with this reagent. Heteroaryl halides, sterically hindered partners, sensitive functional groups, catalyst poisoning, and protodeboronation can affect the outcome. I therefore recommend a small-scale compatibility study before committing to a large purchase or making a direct process transfer.
Start by confirming the exact name, CAS number, structure, formula, and molecular weight. Buyers should make sure that 4-Trifluoromethylphenylboronic acid is not being confused with a positional isomer, a protected boronate ester, or another trifluoromethyl-substituted boronic acid. The intended reaction may require the free boronic acid specifically, while some routes may be designed around an ester alternative.
Specify the minimum assay or purity requirement, analytical method, and any limits for related compounds. For early discovery work, a standard research specification may be sufficient; for a regulated or manufacturing route, additional controls may be necessary. I suggest asking for the current COA, analytical method references where available, and a statement of the batch or lot represented by the data.
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Do not select a package size based only on the theoretical reaction scale. Include expected assay correction, reaction development losses, repeat experiments, sampling, and contingency material. A buyer moving from a 1 mmol experiment to a kilogram-scale process should reassess quality, packaging, transport, and supply continuity rather than simply multiplying the laboratory requirement.
Ask for the SDS and supplier-recommended storage conditions before receiving the product. Packaging should protect the material from unsuitable environmental exposure and should support traceability after opening. I also recommend confirming the shipping classification, export documentation, delivery location, and whether the supplier can provide consistent lots for future orders.
| Specification Area | What to Confirm |
|---|---|
| Identity | CAS 128796-39-4, chemical name, structure, and analytical identity |
| Assay or purity | Acceptance value, test method, and whether the result is reported on an as-is basis |
| Physical description | Recorded appearance and any relevant form or handling information |
| Impurities | Related substances, residual solvents, inorganic residues, and water where applicable |
| Documentation | COA, SDS, batch number, packaging details, and traceability information |
I avoid presenting a single universal purity value when the customer’s application and supplier specification have not been defined. A quoted percentage should always be connected to a test method and a specific batch. This approach reduces the risk of comparing suppliers using labels that appear similar but are analytically different.
The price of 4-Trifluoromethylphenylboronic acid can depend on requested quantity, purity, documentation, packaging, production status, and destination. A small research package may carry a different unit cost from a process-development or recurring manufacturing order. Minimum order quantity is also not necessarily fixed across all grades or package configurations.
Lead time should be confirmed for the exact quantity and specification rather than inferred from a general product listing. Stock availability, batch release, additional testing, export review, and transportation can all influence the final schedule. When I prepare a quotation, I encourage buyers to provide the target quantity, destination, required documents, desired delivery window, and any special quality conditions so the response can be practical.
These questions are especially important when the material is part of a longer synthesis or a regulated development program. A low quoted price does not compensate for an unsuitable specification, incomplete documentation, or an unreliable replenishment plan. I recommend comparing the complete supply package rather than comparing price per gram alone.
One common mistake is ordering by name only without checking the position of the trifluoromethyl group. Another is assuming that a free boronic acid and a boronate ester can be substituted without rechecking reaction performance, molecular weight, and stoichiometry. Buyers may also overlook the difference between nominal purity and the analytical result reported for a specific batch.
A further risk is waiting until the final process stage to assess supply continuity. If a route depends on this building block, it is better to evaluate sample quality, documentation, packaging, and repeat-lot feasibility during development. This gives the project team time to address process sensitivity or sourcing constraints before scale-up.
At Maison Chemical, I approach 4-Trifluoromethylphenylboronic acid sourcing as a technical and commercial coordination task. I can review the requested CAS number, target quantity, quality requirements, packaging expectations, destination, and documentation needs before preparing a suitable quotation. Where the application requires additional discussion, I can help organize the information needed for a more relevant supplier response.
For repeat buyers, I recommend establishing a clear product specification and retaining approved documentation for future lots. For first-time buyers, a sample or smaller development quantity may be a sensible way to evaluate compatibility before expanding the order. Availability, MOQ, price, and delivery should be confirmed for each individual inquiry because they depend on the requested conditions.
If you need 4-Trifluoromethylphenylboronic acid CAS 128796-39-4, the right purchasing decision is not based on the chemical name alone. Confirm the free boronic acid identity, define the required analytical specification, assess the intended coupling application, and review the supplier’s documentation and delivery capability. These steps help reduce avoidable technical and supply risks.
To request support from Maison Chemical, send your required quantity, purity or specification, packaging preference, destination, target delivery date, and document requirements. I can then help assess the appropriate supply route and prepare a B2B quotation for your research, development, or manufacturing program.
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