4-Pyrazoleboronic acid pinacol ester, CAS 269410-08-4, is a pyrazole building block that carries a pinacol boronate group at the 4-position. Chemists commonly consider it for palladium-catalyzed Suzuki–Miyaura coupling, where the boronate can help introduce the pyrazole ring into a larger molecule. Its suitability for a project depends on the intended reaction, the required quality profile, and how the material will be handled and stored. This guide explains those considerations and outlines what to confirm with a supplier before placing an order.
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This guide is intended for medicinal chemistry teams, process development groups, procurement professionals, and chemical distributors evaluating CAS 269410-08-4. It is useful when you are comparing potential pyrazole building blocks or preparing an inquiry for a research or development project. It is not a substitute for a lot-specific certificate of analysis, safety data sheet, or internal process assessment. Confirm technical and commercial details with the supplier before committing material to a defined use.
The compound is also described as a pyrazole-4-boronic acid pinacol ester or a 4-(pinacolboron)-1H-pyrazole derivative. Structurally, it combines a pyrazole ring with a pinacol-protected boron group, making it a boronic ester building block rather than a finished active ingredient. Its reported molecular formula is C9H15BN2O2, corresponding to a molar mass of approximately 194.04 g/mol. Buyers should still verify the identity and formula against the supplier’s product documentation for the offered material.
In Suzuki–Miyaura coupling, an organoboron compound can react with a suitable aryl or vinyl electrophile under an appropriate catalytic system to form a carbon–carbon bond. For this product, the reaction can provide a route to attach a pyrazole fragment to another molecular component. The outcome depends on the partner, catalyst, base, solvent, reaction conditions, and substrate compatibility. The presence of a boronate group indicates a possible synthetic role; it does not guarantee a particular yield or performance in a buyer’s process.
Pyrazole-containing structures appear in a range of research programs, so this building block may be useful when a project needs to explore that heterocycle within a larger compound series. It can support the preparation of intermediates for research and development, subject to the project’s chemistry and controls. Buyers should distinguish research or development use from any intended regulated manufacturing application. Material qualification, supplier documentation, and process validation requirements may differ substantially between these stages.
The compound may be considered when route design calls for forming a bond between the pyrazole 4-position and an appropriate coupling partner. Before scale-up, chemists typically assess conversion, selectivity, impurity formation, work-up, and reproducibility for their own reaction system. Pyrazole nitrogens can also affect coordination or reactivity in some catalytic settings, so conditions optimized for another substrate may not transfer directly. Evaluate the exact substrate pair experimentally rather than relying on the building block’s name alone.
There is no single specification that suits every project, and the figures below should not be read as guaranteed specifications for a particular lot. Ask the supplier for the current product specification and a lot-specific certificate of analysis where available. Compare the offered limits with your intended reaction, analytical methods, and quality system. If a requirement is essential, state it before requesting a quotation so the supplier can confirm whether it can be supported.
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| Specification area | What to confirm | Why it matters |
|---|---|---|
| Identity | Product name, CAS number, and available identity test | Helps confirm that the quoted material matches the requested building block. |
| Assay or purity | Reported value, test method, and acceptance criteria | Impacts material calculation and may influence reaction assessment. |
| Water and impurities | Reported limits or results, where tested | Can be relevant to moisture-sensitive handling or project-specific impurity controls. |
| Appearance and packaging | Lot description, container type, and proposed pack size | Supports receiving, storage, and laboratory handling decisions. |
| Documents and shipment | Available COA and SDS, country of origin if needed, and dispatch estimate | Helps with internal review, safe handling, and procurement planning. |
Start by identifying whether the material is for screening, route development, scale-up, or another defined purpose. Document the target quantity, intended reaction, required assay, and any limits for water or specified impurities. If your team uses different acceptance criteria at different development stages, explain which stage applies to the requested order. Clear requirements make supplier responses easier to compare.
Do not select a grade based only on a product label or an advertised purity figure. Confirm the test method and whether the stated result is a release specification, a typical value, or a result for a particular lot. As an illustration of how to frame a request—not as a product claim—a buyer might ask whether an assay target of at least 95% or at least 98% can be offered and documented. Set the appropriate threshold through your own technical and quality review.
Review the SDS and supplier handling guidance before opening or using the material. Ask how the product should be packaged and stored, and whether the supplier has specific recommendations for protecting it from moisture or other environmental exposure. Do not infer a storage temperature or shelf life from the compound class alone. For a process-critical use, confirm handling conditions with the supplier and validate them within your own procedures.
Request a quotation that identifies the offered pack size, price basis, minimum order quantity, estimated lead time, shipping terms, and any applicable document charges. Lead times and order quantities can vary with stock status, production planning, destination, and requested packaging. Ask whether the quoted schedule is an estimate or a confirmed dispatch commitment. Compare quotations on the same basis, including the required quality documents and delivery conditions.
Before placing an order, check that the supplier can clearly identify the offered product and explain which lot documents are available. Confirm whether the specification and analytical methods meet your stated requirements, and ask how packaging and shipment will be managed. Request clarification on MOQ, lead time, quotation validity, and any restrictions that apply to your destination. If you require additional testing or a particular document format, discuss feasibility before purchase rather than assuming it is included.
Maison Chemical supports B2B inquiries for 4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 and can discuss requested quantities, product documentation, and shipping requirements. Availability, specification, and commercial terms should be confirmed at the time of inquiry. Share your intended use and acceptance criteria so we can respond against the actual procurement need. Any lot-specific results should be reviewed before the material is approved for use.
4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 is a pyrazole boronate building block that may suit projects involving Suzuki–Miyaura coupling and related route development. Whether it is appropriate depends on the target transformation, the offered lot’s specification, and your handling and documentation requirements. The most reliable next step is to prepare a concise inquiry stating quantity, intended use, assay expectations, required documents, destination, and timing. Contact Maison Chemical to discuss availability and request a quotation aligned with those requirements.
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