1-Methyl-4-pyrazole boronic acid pinacol ester, commonly described as 1-methyl-1H-pyrazole-4-boronic acid pinacol ester, is an organoboron compound used as a building block in synthetic chemistry. Its boronate ester group can serve as a coupling partner in palladium-catalyzed carbon–carbon bond formation, including Suzuki–Miyaura reactions. The compound is identified by CAS Registry Number 761446-44-0; its commonly reported molecular formula is C10H17BN2O2 and its molecular weight is approximately 208.07 g/mol. For procurement, buyers should confirm the exact identity, lot-specific assay, analytical documentation, packaging, and availability with the supplier before placing an order.
The molecule combines a 1-methylpyrazole ring with a boron-containing pinacol ester at the ring’s 4-position. A boronic ester is an organoboron functional group in which boron is bound to oxygen atoms from an ester-forming diol; here, the diol component is pinacol. This structure provides a handle that chemists may use in bond-forming reactions, while the methylated pyrazole is retained as part of the intended product structure.
The identity is commonly expressed as 1-methyl-1H-pyrazole-4-boronic acid pinacol ester, although naming conventions can vary between catalogs and suppliers. The CAS number, 761446-44-0, helps distinguish the substance during quotation, documentation review, and inventory setup. The molecular formula C10H17BN2O2 and molecular weight of approximately 208.07 g/mol are useful cross-checks, but they do not replace structure and batch-document verification.
Before purchasing, compare the supplier’s product name and CAS number with the structure required by your route. Confirm that the boronate is attached at the intended pyrazole position and that the N-methyl group is part of the specified structure. If your internal database uses a synonym or drawing, include it in the inquiry to reduce the risk of ordering a related pyrazole or boronic acid derivative.
The compound’s principal synthetic role is as a heteroaryl boronate building block. In suitable reaction systems, organoboron compounds can participate in Suzuki–Miyaura cross-coupling to form carbon–carbon bonds with an appropriate coupling partner. Whether this particular reagent is suitable for a given transformation depends on the reaction design, partner, catalyst, solvent, base, and operating conditions; buyers should consult validated literature or develop conditions for their own route.
The pyrazole ring is a nitrogen-containing heteroaromatic motif that may be incorporated into medicinal chemistry compounds, research intermediates, or other fine-chemical targets. The boronate group offers a route-planning option for connecting that motif to another molecular fragment. This describes a potential synthetic application, not a claim that the material is approved for a particular drug, product, or end use.
These scenarios are not guarantees of reaction performance. A project team should assess compatibility, conversion, impurity formation, work-up, and isolation using its own reaction and analytical methods. For regulated or tightly controlled development programs, material acceptance criteria should be set by the buyer’s quality and technical teams.
When sourcing, “material options” usually refers to supply and quality parameters rather than a different chemical form. A supplier may quote different quantities, packaging configurations, or specification targets depending on availability and order requirements. Do not assume that a different package size or catalog listing represents a different grade unless the supplier’s documents explicitly say so.
Related materials, such as the corresponding boronic acid, a different pyrazole boronate, or a compound with a different ring substitution pattern, are not interchangeable by name alone. Their reactivity and suitability may differ, and changing a reagent can require route or process evaluation. If your project can accept alternatives, provide the required structure and functional role so the supplier can discuss options without treating them as identical products.
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A product specification should give the buyer enough information to decide whether a particular lot fits the intended use. The exact values should come from the supplier’s current specification and lot documentation; they should not be inferred from a catalog title or from the CAS number. Review the following items before approval:
| Specification item | What to confirm | Why it matters |
|---|---|---|
| Identity | Product name, CAS number, structure, and identity test | Helps confirm the requested substitution pattern and material identity. |
| Assay or purity | Reported value, test method, and whether the result is lot-specific | Supports material acceptance and reaction charge calculations. |
| Impurity profile | Available chromatographic or other analytical information | May be relevant to route performance and downstream impurity control. |
| Physical description | Reported appearance and any acceptance criteria | Provides a basic check during receipt and inspection. |
| Storage and handling | Supplier-recommended conditions, shelf life, and handling precautions | Helps preserve the material under the conditions stated by the supplier. |
| Packaging | Container type, net quantity, and shipment protection | Allows the buyer to assess handling and logistics needs. |
For reaction planning, the reported molecular weight of approximately 208.07 g/mol provides a calculation basis: 1 mmol corresponds to approximately 208.07 mg of pure compound. This is a theoretical conversion calculated from molecular weight and does not account for assay, handling loss, or weighing uncertainty. Use the lot-specific assay and your internal procedures when calculating actual charges.
Evaluate the supplier on documentation and communication as well as price. Ask whether the quotation refers to CAS 761446-44-0, what quantity is available, and whether the offered specification matches your application. Request a current Certificate of Analysis for the relevant lot, and clarify which analytical methods and results it includes.
For projects with defined quality requirements, share those requirements before quotation rather than after a purchase order is issued. This gives the supplier an opportunity to confirm whether the offered material and documentation can meet the buyer’s needs. If no public specification is available, request written confirmation of the proposed acceptance criteria and any limitations before proceeding.
Maison Chemical supports B2B sourcing inquiries for 1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0. Buyers can provide the required quantity, intended use, target specification, destination, and preferred delivery timing so the inquiry can be assessed against current supply information. Availability, lead time, packaging, and documentation should be confirmed for the specific order rather than assumed from a general product description.
For a more useful quotation, include your required assay or quality criteria and state whether a lot-specific Certificate of Analysis or other documents are needed. If your team is comparing this ester with a related boron reagent, identify the exact structure and reaction role under consideration. Maison Chemical can then discuss the sourcing request and clarify which details are confirmable for the offered lot.
1-Methyl-4-pyrazole boronic acid pinacol ester is a pyrazole-containing organoboron building block with potential use in cross-coupling and synthetic development. CAS 761446-44-0, the stated structure, and the commonly reported molecular weight of approximately 208.07 g/mol provide useful identity checks, but procurement decisions should rely on current supplier documentation. The compound’s suitability depends on the intended route and the quality requirements of the project.
Before ordering, send Maison Chemical your target quantity, structure or product identifier, specification requirements, destination, and documentation needs. Review the quotation and lot-specific documents, then confirm that the material fits your technical and purchasing criteria. This process gives your team a clear basis for evaluating identity, quality, and supply before committing to procurement.
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